We’ve been told time and time again by doctors and pharmacists not to mix prescription medication with alcohol. Why? Because alcohol can severely counteract the effects of other drugs and create possibly fatal outcomes. Can the same thing happen when you consume a CBD edible or pill with your blood pressure medication? That’s what we’re here to determine.

Cytochrome P450

Cytochrome P450 is an enzyme found in the liver that’s responsible for metabolizing CBD and over 60% of pharmaceutical drugs. As your metabolism determines how quickly a substance is processed through your system, instances that alter it can have bad side effects. When the liver metabolizes CBD, the cytochrome P450 enzyme puts all it’s attention on this drug, essentially ignoring others that are present.

This is dangerous if you’ve decided to take a pharmaceutical like oxycodone with your CBD dosage. The enzyme will work on metabolizing the CBD, why the oxycodone floats around your system for longer than is recommended. As prescription drugs are given with specific time frames in mind regarding how long it should stay in your body, having them linger in your system can cause side effects like dizziness and nausea. It can also result in liver damage with regular use, slowing your metabolism indefinitely.

So what can you take with CBD?

If you start medicating with CBD, your doctor will have to lower the dosage of your other medications. Any drug in your system will be affected when the cannabinoid is in the picture. From antibiotics to antidepressants, it will all be affected once CBD is thrown into the mix. This is why it’s important to talk to your doctor before combining medications.

While more research needs to be done in terms of the specific effects of CBD and it’s interaction with other medications, your doctor will be able to talk to you about your options. They’ll also be able to monitor your health if this is a medical practice you’d like to pursue.

Smoking While Medicated

Does all of this mean you can’t smoke weed while taking other medications? As we’ve been discussing the consumption of CBD through your organs, smoking it will have a different effect when interacting with other medication. As consuming CBD through other means that don’t include ingestion, the drug won’t have nearly as much of an effect on your liver and metabolism as eating it would. Unless you’re using a CBD heavy strain, most cannabis strains contain less than one percent CBD per gram. As long as you don’t try to smoke dozens of grams of cannabis bud in one go, it’s fine to smoke it recreationally while taking other medications.

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